Why Methylation Matters Methylation is one of the body’s essential biochemical “switches.

(Writer: Jaime Hernandez, Medical Exercise Specialist)

: Educational only—not medical advice, diagnosis, or treatment.

Why Methylation Matters

Methylation is one of the body’s essential biochemical “switches.”Think of it as a master regulatory system that helps your body turn key pathways on and off with precision.

When methylation functions optimally, it supports:

• Neurotransmitter balance (mood stability, memory, clarity)

• Detoxification (efficient removal of metabolic waste)

• Cardiovascular & metabolic health

• Eye & bone integrity

• Muscle recovery & energy production

• Fertility & hormone pathways

• Redox/antioxidant defense (cell protection + resilience)

*Optimal methylation = smoother biochemical traffic → improved whole-body function.

What’s Inside Thorne’s Methylation Stack

1. Methyl-Guard Plus®

A comprehensive, clinically sophisticated formula providing the active, bioavailable, and genetically accessible nutrient forms required for efficient methylation.*

Key Active Ingredients & Their Roles

• Betaine (Trimethylglycine)Donates methyl groups to maintain healthy homocysteine levels.*

• 5-MTHF (Active Folate)Bypasses common genetic methylation bottlenecks (like MTHFR variations).*

• Methylcobalamin (Active B12) supports neurological pathways, cognitive clarity, and cellular energy.*

• P5P (Active Vitamin B6)Essential cofactor for homocysteine metabolism and amino acid conversions.*

• R5P (Active Vitamin B2) supports enzymatic reactions across methylation and energy pathways.*

Benefits You Can Feel

• Cardiovascular support*

• Cognitive clarity*

• Positive mood and neurological support*

• Bone health*

• More efficient detoxification pathways*

👉 Thorne Link: https://s.thorne.com/6b0oz

2. Vitamin D-5,000 (D-5000)

A high-potency D₃ that indirectly supports methylation by influencing homocysteine metabolism.*

Why It Matters

• Participates in methylation and homocysteine pathways*

• Supports bones, muscles, and vascular health*

• Reinforces the immune system*

• Supports mood + nervous system resilience*

For Heather: a grounding nutrient for immune-hormonal balance.For Sam: vital for bone density and fall prevention.For Paul: essential in musculoskeletal recovery pathways.

3. Magnesium CitraMate

A highly absorbable blend of magnesium citrate + dimagnesium malate for optimal tissue uptake.*

Why Magnesium Is Essential

• Required in 300+ biochemical reactions

• Supports cardiovascular and vascular function*

• Enhances brain + nervous system performance*

• Needed for bone formation and ATP (energy) production*

• Improves muscle relaxation, lung function, and recovery*

Magnesium is often underrated—yet it steadies the nervous system, supports movement quality, and improves sleep and tissue repair.

⭐ Mini Summary

THE METHYLATION STACK: 3-PART SYSTEM

Methyl-Guard Plus® → The Core Switch

Active folate • Active B12 • Active B6 • R5P • Betaine Purpose: balanced homocysteine, brain clarity, detox pathways.*

Vitamin D-5,000 → The Regulatory Support

Bone • Muscle • Immune • Methylation pathwaysPurpose: supports homocysteine metabolism + healthy cell signaling.*

Magnesium CitraMate → The Catalyst

Enzymes • Energy • RelaxationPurpose: supports 300+ reactions, muscle recovery, heart + nervous system.*

Thank you for your time and energy… Be well.—

Jaime Hernandez, LMT, MES, CPT

Founder, Health and Exercise Prescriptions®www.healthandexerciseprescriptions.com

Thorne Store: https://www.thorne.com/u/HealthAndExercisePrescriptions